The choice of L-tyrosine is based on the fact that it is an efficient, bi-functional, , The yield of the reaction is optimum under grinding method using L-tyrosine (10 , for various organic reactions such as Biginelli reaction, but Scheme 1 Synthesis of 3 , electronic structure calculation by density functional theoretical methods....
application of grindstone method is evident from the fact that, many reactions like Reformatsky reaction (Tanaka et al, 1991), Aldol condensation (Toda et al, 1990), Dieckmann condensation (Toda et al, 1998), Knoevenagel condensation (Ren et al, 2002), Biginelli reaction (Ren et al, 2004), synthe-...
eco-friendly method as we have used requisite amount of solvent for adsorption of reactants at pre-stage of reaction So, to increase the greenness of the reaction we developed a method by grindstone technology It is a simplified pro-cess for conducting the multi-component Biginelli reaction whereby solvent-free chemical reactions occur by ....
Grindstone chemistry: A highly efficient and green method for synthesis of 3,4-dihydropyrimidin-2(1H)-ones by L-tyrosine as an organocatalyst: A combined experimental and DFT study , have tions can be performed in good yield using mortar and pestle been reported only2a Grindstone chemistry has been shown to be a very useful Hitherto, all ....
Journal of Chemical and Pharmaceutical Research _____ ISSN No: 0975-7384 CODEN(USA): JCPRC5 J Chem Pharm R, 2011, 3(6):1089-1096 1089 Multicomponent Biginelli Synthesis of 3,4-dihydropyrimidin-2(1 H)-ones by grindstone technique and evaluation of their biological properti S Jayakumar and T K Shabeer *...
Dihydropyrimidinone/thione by Grindstone Technique : A Green chemistry Approach G M Nazeruddina*, , In the present work Biginelli reaction was accomplished just by grinding equimolar quantities of ethyl , MATERIALS AND METHODS All melting ,...
A simplified green chemistry approach to the Biginelli reaction using!Grindstone Chemistry" Ajay K Bose,a,* Suhas Pednekar,a Subhendu N Ganguly,a Goutam Chakrabortyb and , tween liquid reagents by the grinding method If the reaction products are water soluble, the work-up of...
Grindstone Chemistry: A Highly Efficient and Green Method for Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones by L-Tyrosine as an Organocatalyst: A Combined Experimental and DFT Study...
COMPARATIVE STUDIES OF LEWIS ACIDITY OF ALKYL-TIN CHLORIDES IN MULTICOMPONENT BIGINELLI CONDENSATION USING GRINDSTONE CHEMISTRY TECHNIQUE , Compared to classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity Further, comparative efficiency of alkyl- tin ....
The important feature of this method is that 2-furaldehyde furnished the desired products , the Biginelli reaction of aldehydes, acetoacetate esters, and urea to afford dihydropyrim-idinon , toluenesulfonic acid using grindstone chemistry has been developed by Bose et al29 (Scheme 6) This technique is convenient, time-saving, and also ....
Lithium-acetate-mediated Biginelli one-pot multicomponent synthesis under solvent-free conditions and cytotoxic activity against the human lung cancer cell line A549 and breast cancer cell line MCF7...
The Scientific World Journal is a peer-reviewed, Open Access journal that publishes original research, reviews, and clinical studies covering a wide range of subjects in science, technology, and medicine The journal is divided into 81 subject areas...
application of grindstone method is evident from the fact that, many reactions like Reformatsky reaction (Tanaka et al, 1991), Aldol condensation (Toda et al, 1990), Dieckmann condensation (Toda et al, 1998), Knoevenagel condensation (Ren et al, 2002), Biginelli reaction (Ren et al, 2004), synthe-...
A Simplified Green Chemistry Approach to the Biginelli Reaction Using ?Grindstone Chemistry? Article in ChemInform 36(7) February 2005 with 490 Reads DOI: 101002/chin200507144...
E ISSN: 0975 8232; P ISSN: 2320 5148 , Biginelli reaction However, method is limited and mostly required long time2 The combination of an aldehyde, β-keto ester, and , being energy efficient Grindstone Chemistry also results in high reactivity and less waste products...
International Letters of Chemistry, Physics and Astronomy 2014 , is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using conventional method and grindstone chemistry technique , P Biginelli, Chem Ber 24 (1891) 1317 [2] F Makaev, E Styngach, V Muntyanu, S Pogrebnoi, Russian Journal of Organic ....
The Biginelli product, dihydropyrimidinone (DHPM) core, and its derivatives are of immense biological importance There are several methods reported as modifications to the original Biginelli reaction Among them, many involve the use of different catalysts , (DHPMs) using solvent-free grindstone chemistry method All the synthesized ....
COMPARATIVE STUDIES OF LEWIS ACIDITY OF ALKYL-TIN CHLORIDES IN MULTICOMPONENT BIGINELLI CONDENSATION USING GRINDSTONE CHEMISTRY TECHNIQUE , Compared to classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity Further, comparative efficiency of alkyl- tin ....
Compared to classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity Further, comparative efficiency of alkyl- tin chlorides in multicomponent Biginelli Condensation Reaction ,...
free grindstone method Till date this is the first of its kind study where a grindstone multi component condensation reaction is being performed in a completely solvent free and catalyst free condition Although the usage of clove as catalyst for Biginelli reaction is well documented in literature15....
The syntheses of dihydropyrimidinones (DHPMs) using solvent-free grindstone chemistry method All the synthesized compounds exhibited significant activity against pathogenic bacteria , Moreover, the classical Biginelli reaction requires long reaction times (20 h) and often suffers from low yields of products in case of substituted aromatic ....
3-Amino-2,4-dicarbonitrile-5-methylbiphenyls are synthesized by a three-component reaction of aromatic aldehydes, malononitrile, and acetone in the presence of catalytic NaOMe under grindstone method...
Tapas AR, Magar DD, Kawtikwar PS, Sakarkar DM, Kakde RB, Microwaves in drug discovery and development: A Review, International Journal of PharmTech Research 2009; 1(4): 1039-1050 Biginelli P, Aldehyde-urea derivatives of aceto- and oxaloacetic acids...
a catalyst for Biginelli condensation reaction using Grindstone Technology RESULTS AND DISCUSSION 24and exploiting the inherent capacity of Biginelli reaction to be promoted by acids, in this communication a novel, simple and effective modification of Biginelli reaction is reported The procedure using the grindstone technique is...
The important feature of this method is that 2-furaldehyde furnished the desired products , the Biginelli reaction of aldehydes, acetoacetate esters, and urea to afford dihydropyrim-idinon , toluenesulfonic acid using grindstone chemistry has been developed by Bose et al29 (Scheme 6) This technique is convenient, time-saving, and also ....
River Monsters - Wikipedia River Monsters is a British and American wildlife documentary television programme produced , rivers and lakes to uncover the creatures behind local folklore and harrowing tales of monster fish , men were found to have bled to death in the Sepik river as a result of a "ball cutter" attacking villagers ....
The syntheses of dihydropyrimidinones (DHPMs) using solvent-free grindstone chemistry method All the synthesized compounds exhibited significant activity against pathogenic bacteria , Moreover, the classical Biginelli reaction requires long reaction times (20 h) and often suffers from low yields of products in case of substituted aromatic ....
Brønsted Base-Catalyzed One-Pot Three-Component Biginelli-Type Reaction: An Efficient Synthesis of 4,5,6-Triaryl-3,4-dihydropyrimidin-2(1H)-one and Mechanistic Study , Grindstone chemistry: a highly efficient and green method for synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by l -tyrosine as an organocatalyst: a combined experimental and ....
grinding method in green chemistry a green chemistry strategy , ful preparative method Most of the recent work , ated by grinding (known as Grindstone Chemistry inof the major targets in green chemistry is to limit the extensive use of solvents ....
Comparative study of chemical synthesis of pyrimidine derivatives by using Grindstone chemistry Technique and Conventional method Ratnamala m ponawane The Institute of Science, Mumbai 400032, India E-mail address: [email protected] ABSTRACT The majority of the drugs on the market today are entirely chemically synthesized in the laboratory...